Go natural with CBD! This has become one of the biggest health trends as of late, and for good reason. CBD is a natural compound that has a multitude of health benefits. And unlike THC, this cannabis compound is non-psychoactive. It is perfectly legal, safe to use, and effective on a variety of levels. Whether you are trying to reduce pain from an injury or nurse inflammation from sickness or aging, CBD Pain Cream is your ticket to a pain-free life!  † And now you can try it first before buying. To view your ordering options, simply click the banner below!

First of all, you need to know that CBD oil can come from both the hemp plant and from medical marijuana.  Both of those plants are different varieties of cannabis but they’re much different in the terms of chemical compounds they have.  Medical marijuana is good for people with certain ailments because it does contain the THC and it can contain any varying level of the THC or any varying level of CBD.
In a Phase II double-blind, randomized, placebo-controlled, 5-week study of 56 rheumatoid arthritis patients with Sativex (Blake et al 2006), employed nocturnal treatment only to a maximum of 6 sprays per evening (16.2 mg THC + 15 mg CBD). In the final treatment week, morning pain on movement, morning pain at rest, DAS-28 measure of disease activity, and SF-MPQ pain at present all favored Sativex over placebo (Table 1).

^ Advocates of legalizing marijuana for recreational use, such as Illinois state Senator Heather Steans, has said that legalizing it would help reduce such hazardous added drugs: "Over 95 percent are buying it on the black market. You don’t know what you’re buying. It’s not a safe product. We’ve seen it laced with rat poison, fentanyl, all sorts of things. It’s funding the cartels and other criminal activity."[81]
Although hemp and marijuana are essentially different cultivars of the same plant – Cannabis sativa L – marijuana has been cultivated to concentrate high levels of THC (frequently as much as 18%), in the plant’s flowering tops, whereas hemp, which is primarily grown in Europe to make clothing, paper, biofuels, bioplastics, nutritional supplements, cosmetics, and foods, contains less than 0.3% THC.
If you act today, you can see results and save money with CBD Pain Cream. Because, right now, CBD Pain Cream is offering a discount to all first-time customers. You can get your coupon in your email if you act today. Then, you get to save some money on this life changing solution. If you’re tired of being dependent on expensive and dangerous prescription drugs, this is for you. Don’t let pain hold you back anymore! Your life is worth more than that. Get on with your life and live pain-free with your CBD Pain Cream order. It’s going to make life so much easier.
Cannabidiol (CBD), a non-psychoactive segment of the marijuana plant, has created huge enthusiasm among researchers and physicians.  CBD Oil applies its remedial effect on an atomic level is as yet being sorted out. Cannabidiol is a pleiotropic sedate in that it produces numerous impacts through various atomic pathways. CBD Oil acts through different receptor-free channels and by official with various non-cannabinoid receptors and particle channels.
I appreciate the Fast delivery and thorough packaging. Had my wife try this last night and she compared it to a different brand hemp product she has been using. She likes your product better, especially because it does not have an awful taste like the other product. it provided some pain relief for her RA and fibro but the initial dosage may not have been enough drops. She tried about 20 droplets and was able to sleep through the night.
Cibaderm® offers a full line of CBD hemp oil body care products. Their CBD Hemp Oil Body Wash contains a unique blend of CBD hemp oil and organic steam-distilled essential oils. The Cibaderm® Body Lotion is packed with 50 mg CBD Hemp Nourish™ to leave the skin silky soft. The Hand Cream contains 25 mg CBD combined with powerful antioxidants like vitamin E. Cibaderm® also offers innovative hemp CBD infused hair care products, including Hemp Shampoo and and CBD Hemp Soft™ Conditioner.
That being said, it was unlikely that the federal government was interested in pursuing individuals complying with state-mandated regulations surrounding legalized cannabis for recreational use, although the CSA law still gives them authority to do so. However, the new Trump administration may change this thinking and users of legal marijuana and legal dispensaries await further action and clarifying rules.
Cannatonic: A potent pain-reliever, Cannatonic hails from Spain and stands as one of the earliest cultivars to be bred for its high CBD content. This cultivar is a cross between MK Ultra and G13 Haze, and it helps relieves anxiety, muscle spasms, pain, and migraines while providing uplifting energy. Cannatonic tends to relax and loosen muscles without locking users to their couches.
Cannabis is mostly used for recreation or as a medicinal drug, although it may also be used for spiritual purposes. In 2013, between 128 and 232 million people used cannabis (2.7% to 4.9% of the global population between the ages of 15 and 65).[28] It is the most commonly used illegal drug both in the world and the United States.[21][28] The countries with the highest use among adults as of 2018 are Zambia, the United States, Canada, and Nigeria.[29] In 2016, 51% of people in the United States had ever used cannabis.[30] About 12% had used it in the past year, and 7.3% had used it in the past month.[31]
Update January 1st, 2018: State laws surrounding CBD are starting to make a grey area even greyer as states such as Indiana are currently seeking to make CBD imported from outside of the state, illegal for residents inside the state that qualify for CBD possession under current state laws. Alaska has made selling hemp based CBD against the law for local marijuana shops to sell, but other stores are still free to sell imported hemp oils. All CBD oils sold at local marijuana shops in Alaska currently, must be produced within the state, under the current state guidelines for marijuana production.
Cannabidiol (CBD) oil is used by some people with chronic pain. CBD oil may reduce pain, inflammation, and overall discomfort related to a variety of health conditions. CBD oil is a product made from cannabis. It’s a type of cannabinoid, a chemical found naturally in marijuana and hemp plants. It doesn’t cause the “high” feeling often associated with cannabis, which is caused by a different type of cannabinoid called THC.
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With President Trump signing off on the Agricultural Improvement Act of 2018 (aka the 2018 Farm Bill) last month, the federal government now fully recognizes hemp as a legal agricultural product. But while many reports are claiming that this means that cannabidiol (CBD) is also legal, that’s not quite correct. With a lot of misinformation flying around, and contradictions between state and federal laws, things are admittedly somewhat confusing. Let’s try to sort things out by answering some questions about hemp, CBD, and what has recently changed in federal law.
But in response to the 2018 Farm Bill, the FDA issued a statement noting that the new legislation preserves the FDA’s authority to regulate cannabis and cannabis-derived compounds like CBD, regardless of its source. It also voiced specific concerns about unsubstantiated health-related CBD claims and iterated the unlawfulness of marketing CBD as a dietary supplement or adding it into food products (read the full FDA statement here). So while hemp cultivation and the extraction of CBD from it may now be legal, what the federal government will allow to be done with CBD products from that point on remains to be seen.
The Marinol patient monograph cautions that patients should not drive, operate machinery or engage in hazardous activities until accustomed to the drug’s effects (http://www.solvaypharmaceuticals-us.com/static/wma/pdf/1/3/1/9/Marinol5000124ERev52003.pdf). The Sativex product monograph in Canada (http://www.bayerhealth.ca/display.cfm?Object_ID=272&Article_ID=121&expandMenu_ID=53&prevSubItem=5_52) suggests that patients taking it should not drive automobiles. Given that THC is the most active component affecting such abilities, and the low serum levels produced in Sativex therapy (vide supra), it would be logical that that patients may be able to safely engage in such activities after early dose titration and according to individual circumstances, much as suggested for oral dronabinol. This is particularly the case in view of a report by an expert panel (Grotenhermen et al 2005) that comprehensively analyzed cannabinoids and driving. It suggested scientific standards such as roadside sobriety tests, and THC serum levels of 7–10 ng/mL or less, as reasonable approaches to determine relative impairment. No studies have demonstrated significant problems in relation to cannabis affecting driving skills at plasma levels below 5 ng/mL of THC. Prior studies document that 4 rapid oromucosal sprays of Sativex (greater than the average single dose employed in therapy) produced serum levels well below this threshold (Russo 2006b). Sativex is now well established as a cannabinoid agent with minimal psychotropic effect.
REM behavior disorder: REM behavior disorder (RBD) is a parasomnia disorder characterized by shouting, becoming physically agitated, or otherwise acting out during sleep. For many, RBD is a symptom of a larger, more serious condition or disorder, such as Alzheimer’s disease or PTSD. CBD oil minimizes the symptoms of RBD, and also alleviates the anxiety and painful symptoms that often accompany disorders that lead to RBD.
There is an exception to sections 201(ff)(3)(B)(i) and (ii) if the substance was "marketed as" a dietary supplement or as a conventional food before the drug was approved or before the new drug investigations were authorized, as applicable. However, based on available evidence, FDA has concluded that this is not the case for THC or CBD. For more information on this provision, including an explanation of the phrase "marketed as," see Draft Guidance for Industry: Dietary Supplements: New Dietary Ingredient Notifications and Related Issues.
We have been using cannabis oil with a 1:1 CBD/THC ratio from “AnnCannMed” in treating my husband with pancreatic cancer with a lot of improvement since 4 weeks and the product is working in a miraculous way beyond our expectations. The medication is working with super proof. We recommend you visit AnnCannMed for your health prescriptions and medical purchases and feel support talking to licensed physicians
CBD’s action within the brain and body is quite complicated. To date, scientists have discovered more than a dozen different mechanisms of action, or ways that CBD affect us. It’s very likely that the beneficial effects of CBD are a result of the total of its activation of all of these biological pathways, not a single one in particular. Much more research is needed to fully understand the mechanisms by which CBD relieves ailments such as anxiety and seizures.
“We continue to estimate a $250-500B potential long-term global cannabis market, with a $15-50B near-term opportunity,” analysts Michael Lavery and Jeffrey Kratky wrote in a note. “We expect intellectual property, value-added products, and form factor evolution to be key long-term drivers for the company.” Piper Jaffray rates the stock as overweight with a $60 price target, equal to 33% upside from its current trading level.
THC and its major (inactive) metabolite, THC-COOH, can be measured in blood, urine, hair, oral fluid or sweat using chromatographic techniques as part of a drug use testing program or a forensic investigation of a traffic or other criminal offense.[52] The concentrations obtained from such analyses can often be helpful in distinguishing active use from passive exposure, elapsed time since use, and extent or duration of use. These tests cannot, however, distinguish authorized cannabis smoking for medical purposes from unauthorized recreational smoking.[149] Commercial cannabinoid immunoassays, often employed as the initial screening method when testing physiological specimens for marijuana presence, have different degrees of cross-reactivity with THC and its metabolites.[150] Urine contains predominantly THC-COOH, while hair, oral fluid and sweat contain primarily THC.[52] Blood may contain both substances, with the relative amounts dependent on the recency and extent of usage.[52]
Sativex® (GW Pharmaceuticals) is an oromucosal whole cannabis-based spray combining a CB1 partial agonist (THC) with a cannabinoid system modulator (CBD), minor cannabinoids and terpenoids plus ethanol and propylene glycol excipients and peppermint flavoring (McPartland and Russo 2001; Russo and Guy 2006). It was approved by Health Canada in June 2005 for prescription for central neuropathic pain in multiple sclerosis, and in August 2007, it was additionally approved for treatment of cancer pain unresponsive to optimized opioid therapy. Sativex is a highly standardized pharmaceutical product derived from two Cannabis sativa chemovars following Good Agricultural Practice (GAP) (de Meijer 2004), yielding Tetranabinex® (predominantly-THC extract) and Nabidiolex® (predominantly-CBD extract) in a 1:1 ratio. Each 100 μL pump-action oromucosal Sativex spray actuation provides 2.7 mg of THC and 2.5 mg of CBD. Pharmacokinetic data are available, and indicate plasma half lives of 85 minutes for THC, 130 minutes for 11-hydroxy-THC and 100 minutes for CBD (Guy and Robson 2003). Sativex effects commence in 15–40 minutes, an interval that permits symptomatic dose titration. A very favorable adverse event profile has been observed in over 2500 patient years of exposure in over 2000 experimental subjects. Patients most often ascertain an individual stable dosage within 7–10 days that provides therapeutic relief without unwanted psychotropic effects (often in the range of 8–10 sprays per day). In all RCTs, Sativex was adjunctively added to optimal drug regimens in subjects with intractable symptoms, those often termed “untreatable.” Sativex is also available by named patient prescription in the UK and the Catalonia region of Spain. An Investigational New Drug (IND) application to study Sativex in advanced clinical trials in the USA was approved by the FDA in January 2006 in patients with intractable cancer pain.
I appreciate the Fast delivery and thorough packaging. Had my wife try this last night and she compared it to a different brand hemp product she has been using. She likes your product better, especially because it does not have an awful taste like the other product. it provided some pain relief for her RA and fibro but the initial dosage may not have been enough drops. She tried about 20 droplets and was able to sleep through the night.
What exactly is cannabidiol (CBD) and more importantly, what does it do? Those questions and more are at the heart of this comprehensive guide to one of the most fascinating and important compounds of the cannabis plant. Cannabis plants are chemical powerhouses that produce more than 400 different compounds. Not all of those compounds are unique to marijuana, of course, and appear in many other species of plants. That’s why marijuana can smell like pine trees or taste like fresh lemons. But of those 400 compounds, more than 60 of them are totally specific to the plant genus Cannabis. Scientists call these special compounds “cannabinoids.” However, not all cannabinoids are created equal. One of them, cannabidiol, or CBD, holds the key to the wide variety of medicinal and therapeutic effects marijuana offers.
Debate continues as to the existence of a clinically significant cannabis withdrawal syndrome with proponents (Budney et al 2004), and questioners (Smith 2002). While withdrawal effects have been reported in recreational cannabis smokers (Solowij et al 2002), 24 volunteers with MS who abruptly stopped Sativex after more than a year of continuous usage displayed no withdrawal symptoms meeting Budney’s criteria. While symptoms recurred after 7–10 days of abstinence from Sativex, prior levels of symptom control were readily re-established upon re-titration of the agent (Wade et al 2006).

The legality of CBD in the US varies from state to state, but at the federal level, CBD is mysteriously classified as a Schedule I drug despite its sourcing. According to the federal government, Schedule I drugs are substances or chemicals with no currently accepted medical use and a high potential for abuse. Other Schedule I drugs include heroin, LSD, marijuana, and ecstasy. However, CBD can be purchased as a dietary supplement throughout the country despite the FDA’s official stance that CBD isn’t a supplement. The landscape of CBD legality in the US is exactly as confusing as it reads; that squirrely, perplexing itch at the back of your brain is cognitive dissonance, and it’s an entirely normal reaction.
Depression? Arthritis? Inflammation contributes to pain, stiffness, and poor health over time. Many individuals opt for CBD to control inflammation. However, THC has a part to play as well. Research suggests that, in some instances, the cannabis compound can decrease the production of cytokine and chemokine compounds in the body. Cytokine and chemokines are immune compounds that trigger inflammation. Additional pre-clinical research suggests that it may be able to decrease inflammation by suppressing genes related to inflammatory response. I believe people deserve access to all parts of the cannabis plant! Together, we can spread the cannabis education not DEA lies! Just as they have done opiates! Also, it’s ridiculous to wage war between the two! Have pain patients saying medical marijuana doesn’t work etc and others saying opiates are bad. There should be access to both – whatever works for someone! I never used marijuana until forced off my opiates cold turkey in cancer recurrence left dying in stage 4 cancer pain! It stopped the pain, vomiting & 2 metastatic tumors gone confirmed via MRI. I’m not claiming it cured it but feel it slowed it down and did kill two tumors. Marijuana/Opiates – WE SHOULD HAVE A CHOICE OR BOTH IF NEEDED! Shame on our Government for all the lies and trying to turn the people against one another. I hate the DEA, CDC, FDA! Just alone at what they allow in our food – the steroids, antibiotics it is sickening! They take away opiates yet cigarettes & alcohol are legal!?!?! What kind of [edit] is that! And marijuana has never caused one death – sch 1. The alcohol/cigarette related addictions/deaths as well as cases of cancer as other terminal illness they cause! Hell we need opiates for the pain from those illnesses from their legal substances they avoid talking about if I keep it real because they sure as hell wont!
A. The Agriculture Improvement Act of 2018 changes certain federal authorities relating to the production and marketing of hemp, defined as cannabis (Cannabis sativa L.), and derivatives of cannabis with extremely low (less than 0.3 percent on a dry weight basis) concentrations of the psychoactive compound delta-9-tetrahydrocannabinol (THC). These changes include removing hemp from the Controlled Substances Act, which means that it will no longer be an illegal substance under federal law. However, Congress explicitly preserved the agency's current authority to regulate products containing cannabis or cannabis-derived compounds under the FD&C Act and section 351 of the Public Health Service Act. Please see the FDA’s statement on the signing of the Agriculture Improvement Act of 2018.
"It would not be an appropriate use of federal resources to go after a mother because her child has epileptic seizures and has found something that can help and has helped. Are they breaking the law? Yes, they are. Are we going to break her door down? Absolutely not. And I don't think she'll be charged by any U.S. Attorney," DEA spokesperson Rusty Payne told the Indiana news station.

In 2015, The Hebrew University of Israel published a study that documented the potency of single-molecule CBD extract versus the potency of whole-plant CBD-rich extract. It found that extract taken from whole plant CBD-rich cannabis is therapeutically superior to single-molecule extract. The scientists behind this study noticed that science had been utilizing pure, single-molecule CBD, which resulted in a bell-shaped dose-response curve. This means that CBD’s efficacy plummets at very high and very low doses.
However, because no tools existed for quality control, it was impossible to prepare a standardized medicine, so patients often received a dose that was either too low, having no effect, or too high, resulting in serious side effects. Moreover, Cannabis extract was not water-soluble and therefore could not be injected (in contrast to, e.g., the opiates), whereas oral administration was found to be unreliable because of its slow and erratic absorption. Because of such drawbacks, the medicinal use of Cannabis increasingly disappeared in the beginning of the twentieth century, and in 1937 Cannabis was removed from the US pharmacopoeia, a move that was followed by most other Western countries.27 Isolation and structure elucidation of the first pure active substances from Cannabis was not achieved until the 1960s.29
     CBD content in Hemp oil, when extracted from the proper strains, can be very high as Hemp plants are now the very strains that are being used to breed high CBD levels back into Cannabis after years of selective recreational breeding for high THC values. Well known strains such Charlotte's Web are hybrids that were selected from crosses with High CBD Hemp varietals and those Hemp genetics are what account for the new High CBD Strains of Marijuana and commercial Hemp that have and are being developed.
Israel, another example, has led the way with ground-breaking research into cannabis cultivation. The country recently recognized medical marijuana as an official part of the nation’s branch of agriculture. Israel is already one of the world’s leading exporters of medical-grade cannabis. Recognizing marijuana cultivation as an official branch of the country’s agriculture will open up even more funds to support Israeli cannabis farmers.
Cannabis use started to become popular in the United States in the 1970s.[251] Support for legalization has increased in the United States and several U.S. states have legalized recreational or medical use.[281] A 2018 Social Science Research study found that the main determinants of such changes in attitudes toward marijuana regulation since the 1990s were changes in media framing of marijuana, a decline in perception of the riskiness of marijuana, a decline in overall punitiveness, and a decrease in religious affiliation. [282]

The word cannabis is from Greek κάνναβις (kánnabis) (see Latin cannabis),[135] which was originally Scythian or Thracian.[136] It is related to the Persian kanab, the English canvas and possibly even to the English hemp (Old English hænep).[136] In modern Hebrew, קַנַּבּוֹס‬ qannabōs (modern pronunciation: [kanaˈbos]) is used but there are those who have theorized that it was referred to in antiquity as קני בושם q'nei bosem, a component of the biblical anointing oil.[137][138] Old Akkadian qunnabtu, Neo-Assyrian and Neo-Babylonian qunnabu were used to refer to the plant meaning "a way to produce smoke".[139][140][141]
CBD oil alleviates physical pain and anxiety – both of which can have a negative impact on sleep. Additionally, CBD oil can actually prolong sleep for some, leading to more rest from night to night. Most medical experts agree that marijuana is not particularly beneficial for individuals with medical conditions and/or mental health disorders, as the THC can increase their symptoms; this makes CBD oil a good alternative option for people with the following sleep disorders and medical conditions.
CBD shops around Chicago have been hiring more employees to handle increased demand in recent months, and some are considering opening suburban locations. An Ohio-based company said last week that it plans to open 300 shops that sell CBD-infused beauty products at malls throughout the country this year, at least eight of which are set to open in the Chicago area by summer. Until recently, the products were sold mostly online or in vape shops.

Results of a Phase III study (N = 177) comparing Sativex, THC-predominant extract and placebo in intractable pain due to cancer unresponsive to opiates (Johnson and Potts 2005) demonstrated that Sativex produced highly statistically significant improvements in analgesia (Table 1), while the THC-predominant extract failed to produce statistical demarcation from placebo, suggesting the presence of CBD in the Sativex preparation was crucial to attain significant pain relief.
“We continue to estimate a $250-500B potential long-term global cannabis market, with a $15-50B near-term opportunity,” analysts Michael Lavery and Jeffrey Kratky wrote in a note. “We expect intellectual property, value-added products, and form factor evolution to be key long-term drivers for the company.” Piper Jaffray rates the stock as overweight with a $60 price target, equal to 33% upside from its current trading level.
Our family has been making healthy oils and supplements in the Pacific Northwest for nearly 30 years. As a leader in the natural foods industry, we stake our reputation on innovating and creating the quality products our customers have come to expect. And like all of our products, our Ideal CBD Hemp Oil meets the very highest standards of excellence.
I’ve been wanting to know on how to understand the life cycle of a marijuana plant but I don’t know how to get started. I do research on my own, I also read lots of articles but this one caught my attention https://www.bonzaseeds.com/blog/life-cycle-marijuana-plant/ It has the content of all you about to know in planting and to understand the life cycle of marijuana plant.
Cannabis for industrial uses is valuable in tens of thousands of commercial products, especially as fibre[107] ranging from paper, cordage, construction material and textiles in general, to clothing. Hemp is stronger and longer-lasting than cotton. It also is a useful source of foodstuffs (hemp milk, hemp seed, hemp oil) and biofuels. Hemp has been used by many civilizations, from China to Europe (and later North America) during the last 12,000 years.[107][108] In modern times novel applications and improvements have been explored with modest commercial success.[109][110]

Our award-winning support staff, experienced cultivators, and network of healthcare practitioners are here to help remove barriers to medical cannabis. We’re honoured to be part of a movement that’s helping Canadians across the country access their medicine; and as we grow we will continue to provide patients with reliable access to safe, consistent, and effective medical cannabis.
These states are Idaho, Kansas, Nebraska and South Dakota. Now, even though marijuana-derived CBD is legal in these states, the laws are still unclear, so there are still businesses selling CBD, and patients using CBD in these states. We totally believe in the benefits CBD offers and support the CBD movement, but if you are in one of these states, be cautious and careful when considering using CBD products.
Cannabis most likely originates from Central Asia, as archeological evidence indicates that it was already cultivated in China for food and fiber 10 000 years ago. Even in ancient Egyptian mummies, clues have been found for the use of Cannabis as food or medicine.25 In fact, Cannabis is one of the oldest known medicinal plants and is described in almost every ancient handbook on plant medicine, most commonly in the form of a tincture or a tea.26,27 Some religions were closely related with the properties of the Cannabis plant. For example, in Hindu legend, Cannabis is believed to be the favorite food of the god Shiva, because of its energizing properties. As Cannabis spread from Asia toward the West, almost every culture came into contact with this miracle plant. Nowadays, varieties of Cannabis can be found in all temperate and tropical zones, except in humid, tropical rain forests.28
Cannador® (IKF-Berlin) is a cannabis extract administered in oral capsules, with differing figures as to THC:CBD ratios (reviewed in (Russo and Guy 2006)), generally approximately 2:1. Two pharmacokinetic studies on possibly related material have been reported (Nadulski et al 2005a; Nadulski et al 2005b). In a Phase III RCT employing Cannador in spasticity in multiple sclerosis (MS) (CAMS) (Zajicek et al 2003) (Table 1), no improvement was noted in the Ashworth Scale, but benefit was observed in spasm-associated pain on subjective measures. Both Marinol and Cannador produced reductions in pain scores in long-term follow-up (Zajicek et al 2005). Cannador was assayed in postherpetic neuralgia in 65 subjects with no observed benefit (Ernst et al 2005) (Table 1), and in 30 post-operative pain subjects (CANPOP) without opiates, with slight benefits, but prominent psychoactive sequelae (Holdcroft et al 2006) (Table 1). 

Although THC is best known for its mind-altering euphoria, it too has important medical benefits. There’s some overlap in what CBD and THC can treat, but THC is particularly effective in relieving nausea, appetite loss, insomnia, among other symptoms. Many patients find that a balance of CBD and THC offers the best symptom relief as the two work together synergistically.
Cannador® (IKF-Berlin) is a cannabis extract administered in oral capsules, with differing figures as to THC:CBD ratios (reviewed in (Russo and Guy 2006)), generally approximately 2:1. Two pharmacokinetic studies on possibly related material have been reported (Nadulski et al 2005a; Nadulski et al 2005b). In a Phase III RCT employing Cannador in spasticity in multiple sclerosis (MS) (CAMS) (Zajicek et al 2003) (Table 1), no improvement was noted in the Ashworth Scale, but benefit was observed in spasm-associated pain on subjective measures. Both Marinol and Cannador produced reductions in pain scores in long-term follow-up (Zajicek et al 2005). Cannador was assayed in postherpetic neuralgia in 65 subjects with no observed benefit (Ernst et al 2005) (Table 1), and in 30 post-operative pain subjects (CANPOP) without opiates, with slight benefits, but prominent psychoactive sequelae (Holdcroft et al 2006) (Table 1).
It is often claimed by growers and breeders of herbal cannabis that advances in breeding and cultivation techniques have increased the potency of cannabis since the late 1960s and early '70s when THC was first discovered and understood. However, potent seedless cannabis such as "Thai sticks" were already available at that time. Sinsemilla (Spanish for "without seed") is the dried, seedless inflorescences of female cannabis plants. Because THC production drops off once pollination occurs, the male plants (which produce little THC themselves) are eliminated before they shed pollen to prevent pollination. Advanced cultivation techniques such as hydroponics, cloning, high-intensity artificial lighting, and the sea of green method are frequently employed as a response (in part) to prohibition enforcement efforts that make outdoor cultivation more risky. It is often cited that the average levels of THC in cannabis sold in the United States rose dramatically between the 1970s and 2000, but such statements are likely skewed because undue weight is given to much more expensive and potent, but less prevalent samples.[252]

Subsequent studies were carried out in different countries, which confirmed the results found in the Zammit et al. (2002) study, showing that those clinically dependent on cannabis by 18 years of age had an increased risk of later developing psychotic symptoms (Fergusson, Horwood, & Swain-Campbell, 2003). Cannabis users were also more likely to develop schizophreniform disorder (Arseneault et al., 2002), and the dose–response relationship found in the first study was confirmed (Henquet et al., 2005).
Chronic pain: The body’s ECS plays a role in alleviating and managing pain, so CBD oil can work as a supplement for individuals with medical conditions that cause chronic pain, such as arthritis and multiple sclerosis. CBD oil also increases levels of adenosine in the brain; adenosine is a neurotransmitter that aids cardiovascular function and eases painful inflammation.

For many, the medical and therapeutic potential of cannabis is what makes legalizing the marijuana plant such an important political and social task. Federal prohibition has established barriers to comprehensive cannabis research in the United States. However, researchers in other countries continue to make significant contributions to our knowledge of the cannabis plant and how it affects the human body.
The findings imply that cannabidiol can also be a healthy alternative for patients who have got accustomed to powerful painkiller doses. CBD does not have any steroid properties, and it is an anti-inflammatory drug that is less powerful than analgesics based on opioids. But, CBD is much more prescribed because of its non-side-effect causing properties.

CBD modulates/diminishes the effects of THC so is not a desired trait for recreational strains of cannabis for the most part, unless in very small concentrations. Strains that approach a 1:1 ratio of THC to CBD have little psychoactive effect and are more suitable for medicinal use where high THC doses can be uncomfortable for some. It is only with the recent surge of interest in Cannabidiol that breeders are getting the financial incentive to work with these previously abandoned hemp strains in order to bring CBD back into the Cannabis genetic pool and develope strains such as Charlotte's Web, Cannatonic, ACDC and Harlequin, among many other high CBD variants, some of which now have low enough THC levels to qualify for industrial Hemp status. A great breakdown of some of the most well known High CBD strains being used to make Marijuana oil and extracts in Medical Marijuana states today may be found here via Synergy Wellness's site.
If you act today, you can see results and save money with CBD Pain Cream. Because, right now, CBD Pain Cream is offering a discount to all first-time customers. You can get your coupon in your email if you act today. Then, you get to save some money on this life changing solution. If you’re tired of being dependent on expensive and dangerous prescription drugs, this is for you. Don’t let pain hold you back anymore! Your life is worth more than that. Get on with your life and live pain-free with your CBD Pain Cream order. It’s going to make life so much easier.
Since it started becoming popular roughly two years or so ago, the general consensus has always been that since CBD oil from top brands does not contain the psychoactive properties of THC, it is therefore legal. Unfortunately, its legality is much more nuanced because of conflicting federal laws and new court cases. What is clear is that in one of the most recent court decisions on the topic, Hemp Industries Assoc. v. DEA, which came out on April 30, 2018, the US Court of Appeals for the Ninth Circuit found that Section 7606 of the 2014 US Farm Bill (the “Farm Bill”) preempts the Controlled Substances Act (CSA), the federal law which designates marijuana as a Schedule I substance (along with heroin and cocaine) making it illegal to possess or use. This means that when there is conflict between the CSA and the Farm Bill, the Farm Bill wins out.
^ Russo, E. B.; Jiang, H.-E.; Li, X.; Sutton, A.; Carboni, A.; Del Bianco, F.; Mandolino, G.; Potter, D. J.; Zhao, Y.-X.; Bera, S.; Zhang, Y.-B.; Lü, E.-G.; Ferguson, D. K.; Hueber, F.; Zhao, L.-C.; Liu, C.-J.; Wang, Y.-F.; Li, C.-S. (2008). "Phytochemical and genetic analyses of ancient cannabis from Central Asia". Journal of Experimental Botany. 59 (15): 4171–82. doi:10.1093/jxb/ern260. PMC 2639026. PMID 19036842.
Certain facets of acute cannabinoid exposure, including tachycardia, hypothermia, orthostatic hypotension, dry mouth, ocular injection, intraocular pressure decreases, etc. are subject to rapid tachyphylaxis upon continued administration (Jones et al 1976). No dose tolerance to the therapeutic effects of Sativex has been observed in clinical trials in over 1500 patient-years of administration. Additionally, therapeutic efficacy has been sustained for several years in a wide variety of symptoms; SAFEX studies in MS and peripheral neuropathic pain, confirm that Sativex doses remain stable or even decreased after prolonged usage (Wade et al 2006), with maintenance of therapeutic benefit and even continued improvement.

In 1976, Canadian botanist Ernest Small[66] and American taxonomist Arthur Cronquist published a taxonomic revision that recognizes a single species of Cannabis with two subspecies: C. sativa L. subsp. sativa, and C. sativa L. subsp. indica (Lam.) Small & Cronq.[62] The authors hypothesized that the two subspecies diverged primarily as a result of human selection; C. sativa subsp. sativa was presumably selected for traits that enhance fiber or seed production, whereas C. sativa subsp. indica was primarily selected for drug production. Within these two subspecies, Small and Cronquist described C. sativa L. subsp. sativa var. spontanea Vav. as a wild or escaped variety of low-intoxicant Cannabis, and C. sativa subsp. indica var. kafiristanica (Vav.) Small & Cronq. as a wild or escaped variety of the high-intoxicant type. This classification was based on several factors including interfertility, chromosome uniformity, chemotype, and numerical analysis of phenotypic characters.[52][62][67] 

These mounting developments in the elicited a problem amongst cannabis cultivators across the US: decades of selectively breeding cannabis to achieve the maximum amount of THC for a strong high reduced the overall preponderance of CBD in cultivars across the country to trace lows. Essentially, CBD had been selectively bred out of existence across the country.
I have a brother in law who has been diagnosed with cataplexy and narcoplexy, where he starts quivering and slowly loses control of his body and goes into a sleep, which causes him to drop to the ground with mild seizures while he is out. He lives alone (59 years old), but has smoked cannabis since he (we) were teenagers. He still smokes, and is on medication twice a day for this condition, but if he misses those meds by even half an hour, he is at risk of these seizures. The sad part is, these seizures are usually brought on by the smallest emotional change, usually tension, excitement or, the worst thing, if something he finds funny and is the least bit tickled about and starts to laugh, this process will immediately begin. Does anyone know if this kind of condition is treatable with cbd oil’s or concentrates? As I said, he smokes weed, and often grows his own, but he does it for the high and relaxation advantage, since he is basically home-bound due to this condition ending his work career about 4 years ago. Thanks for any replies. I’d be overjoyed if I could tell him there’s a possible solution to the problem other than his prescriptions. Or even if it worked WITH his meds to keep from having to live such a sedentary life.
Although hemp and marijuana are essentially different cultivars of the same plant – Cannabis sativa L – marijuana has been cultivated to concentrate high levels of THC (frequently as much as 18%), in the plant’s flowering tops, whereas hemp, which is primarily grown in Europe to make clothing, paper, biofuels, bioplastics, nutritional supplements, cosmetics, and foods, contains less than 0.3% THC. 

Along with THC, cannabidiol (CBD) is one of more than a hundred “phytocannabinoids” contained in the Cannabis plant. Relative to the amount of THC in marijuana grown for recreational use, the amount of CBD is trivial, with the proportion of THC to CBD increasingly widening over the past several decades.1 The breeding of cannabis strains with more THC and less CBD has occurred in response to recreational consumer demand. More THC means more of a “high,” whereas CBD — which can oppose some of the effects of THC — doesn’t have any euphoric effects and may interfere with the high produced by THC. So, for the most part, CBD-laden marijuana has not been what recreational users are looking for.

Duchess was diagnosed with cancer in her right anal gland. When the cancer was removed it had spread to her left anal gland and was attached to her bowels. She was given 3 months to live. Since then I have had 2 vets check her glands and have had complete physical. She has a clean bill of health. I am so grateful to you. We are going to start on a maintenance program. I tell everyone how she has done. Thanks
In 2014, the Florida legislature passed SB 1030, which creates a registry ID card system for patients with cancer, seizure disorders, or severe and persistent muscle spasms that would allow them to possess and use only cannabis products rich in cannabidiol (CBD) and low in THC. In November 2016, voters approved Amendment 2, which will create a comprehensive medical cannabis program with significantly expanded qualifying conditions.
The high lipid-solubility of cannabinoids results in their persisting in the body for long periods of time.[139] Even after a single administration of THC, detectable levels of THC can be found in the body for weeks or longer (depending on the amount administered and the sensitivity of the assessment method).[139] A number of investigators have suggested that this is an important factor in marijuana's effects, perhaps because cannabinoids may accumulate in the body, particularly in the lipid membranes of neurons.[140]

“This bill will help get sick children potentially life-changing medicine. By crafting the legislation in a way that allows for tightly controlled medical studies, we can ensure we are researching possible treatments in a responsible and scientific way. The CBD oil we are studying is a non-intoxicating derivative of marijuana. It is not marijuana, and it is not anything that can make you ‘high.’ This law has been narrowly crafted to support highly supervised medical trials for children with debilitating seizures. It is not a first step towards legalizing marijuana, and I will never support the legalization of marijuana in Oklahoma.”
The author of a Harvard-led systematic review of 28 studies examining the efficacy of exo-cannabinoids (cannabinoids formed outside of the body, i.e. from the plant or synthetically made) to treat pain and other medical issues concluded, “the use of marijuana for chronic pain, neuropathic pain, and spasticity due to multiple sclerosis is supported by high-quality evidence.”
Topicals represent a newer emerging market in medical marijuana products geared toward health and beauty. Cannabinoids can be absorbed through the skin for certain therapeutic benefits without any psychoactivity. Additionally, the essential oils in hemp and cannabis provide many benefits for skin health. From moisturizers to shampoos and deodorants, medical cannabis products continue to diversify.
The list includes marijuana (undifferentiated by strain) and heroin. (While the federal government oversees marijuana research, marijuana use is regulated, in part, by state laws.) As a result, scientists who study the compound must follow a host of restrictive rules. Last year, responding to a request from several governors to change marijuana’s designation, the Drug Enforcement Administration announced that all cannabis would remain a Schedule 1 drug.

Hemp seed oil has been dubbed "Nature's most perfectly balanced oil", due to the fact that it contains the perfectly balanced 3:1 ratio of Omega 6 (linolei/LA) to Omega 3 (alpha-linolenic/LNA) essential fatty acids, determined to be the optimum requirement for long-term healthy human nutrition. In addition, it also contains smaller amounts of 3 other polyunsaturated fatty acids in gamma-linolenic acid (GLA), oleic acid and stearidonic acid. The EFA combination is unique among edible oil seeds.


Thapa, D., Toguri, J. T., Szczesniak, A. M., & Kelly, A. E. M. (2017, April 1). The non-psychoactive phytocannabinoid, cannabidiol (CBD), and the synthetic derivatives, HU308 and CBD-DMH, reduces hyperalgesia and inflammation in a mouse model of corneal injury [Abstract]. FASEB Journal. Retrieved from https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.811.7
The Haleigh's Hope Act was signed by Georgia's Governor in 2016. This law has made the use of cannabis oil legal, however, it cannot contain any more than 5% THC. It can also only be used for medical reasons. CBD products from Every Day Optimal contain 0% THC and their items can only be used for medical purposes. The state believes that CBD can have an amazing impact on the lives of people all across the U.S. who are suffering from debilitating health problems.
A 2015 review found that the use of high CBD-to-THC strains of cannabis showed significantly fewer positive symptoms such as delusions and hallucinations, better cognitive function and both lower risk for developing psychosis, as well as a later age of onset of the illness, compared to cannabis with low CBD-to-THC ratios.[278] A 2014 Cochrane review found that research was insufficient to determine the safety and efficacy to using cannabis to treat schizophrenia or psychosis.[279] As of 2017, the molecular mechanisms for the anti-inflammatory and possible pain relieving effects of cannabis are under preliminary research.[280]
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