Pure CBD hemp oil is extracted from the cannabis varieties that are naturally abundant in CBD, and low in THC. A specialized extraction process is used to yield highly concentrated CBD oil or pure cannabidiol that also contains other nutritious material such as omega-3 fatty acids, terpenes, vitamins, chlorophyll, amino acids, and other phytocannabinoids like cannabichromene (CBD), cannabigerol (CBG), cannabinol (CBN) and cannabidivarian (CBCV).
A clinical endocannabinoid deficiency has been postulated to be operative in certain treatment-resistant conditions (Russo 2004), and has received recent support in findings that anandamide levels are reduced over controls in migraineurs (Sarchielli et al 2006), that a subset of fibromyalgia patients reported significant decreased pain after THC treatment (Schley et al 2006), and the active role of the ECS in intestinal pain and motility in irritable bowel syndrome (Massa and Monory 2006) wherein anecdotal efficacy of cannabinoid treatments have also been claimed.
I suffer from Fibromyalgia, spinal stenosis, osteoporosis, arthritis, and 66 yeas of wear and tear. I was overwhelmed by the endless varieties of hemp oil even after reading all the product info, so I chose to go with Amazon’s pick.this has a subtle mint flavor and within 2days, I was seeing a reduction in pain, better mood, and improvements in my brain fog. They have a loyal customer now. Even the headache I have had for 6 months since being put on Gabapentin is gone which means I no longer take Advil like tic tacs!
Chronic pain represents an emerging public health issue of massive proportions, particularly in view of aging populations in industrialized nations. Associated facts and figures are daunting: In Europe, chronic musculoskeletal pain of a disabling nature affects over one in four elderly people (Frondini et al 2007), while figures from Australia note that older half of older people suffer persistent pain, and up to 80% in nursing home populations (Gibson 2007). Responses to an ABC News poll in the USA indicated that 19% of adults (38 million) have chronic pain, and 6% (or 12 million) have utilized cannabis in attempts to treat it (ABC News et al 2005).
The legal problems occur once the extracts contain higher percentages of THC, or when they’re made from cannabis plants that are no longer considered “hemp” (so basically high THC plants). Products with these extracts might be in violation of the United States Controlled Substances Act (US CSA). This is when laws regarding specific states or countries will apply.
As the CBD movement continues to grow, we are very optimistic that both hemp-derived and marijuana-derived CBD will be completely legal in all 50 states within the next 5 years. Of course, it is still very hard to predict the future, especially given the constantly shifting political landscape, but we can continue to push forward, build awareness, and educate the world about the benefits of CBD.
Wyoming has a particularly narrow law for CBD oil. It is only legal for patients with epilepsy that has not responded to other treatments. Neurologists have to give the state's Department of Health a statement about how the patient needs and would benefit from the CBD, made from hemp extract, and then the patient may be able to receive a card that allows them to receive cannabis with high concentrations of CBD and trace amounts of THC.
Other “minor phytocannabinoids” in cannabis may also contribute relevant activity (McPartland and Russo 2001). Cannabichromene (CBC) is the third most prevalent cannabinoid in cannabis, and is also anti-inflammatory (Wirth et al 1980), and analgesic, if weaker than THC (Davis and Hatoum 1983). Cannabigerol (CBG) displays sub-micromolar affinity for CB1 and CB2 (Gauson et al 2007). It also exhibits GABA uptake inhibition to a greater extent than THC or CBD (Banerjee et al 1975), suggesting possible utilization as a muscle relaxant in spasticity. Furthermore, CBG has more potent analgesic, anti-erythema and lipooxygenase blocking activity than THC (Evans 1991), mechanisms that merit further investigation. It requires emphasis that drug stains of North American (ElSohly et al 2000; Mehmedic et al 2005), and European (King et al 2005) cannabis display relatively high concentrations of THC, but are virtually lacking in CBD or other phytocannabinoid content.
I was on a road trip and the pain in my knee and feet was terrible. I saw this at a gas station and bought it. within five minute my pain was gone and I was able to finish my road trip pain free. I stopped back at the gas station to buy 2 more of the little jars so I have one for my purse, my work bag and my husband has one also. I have used it every day for my RA in my feet and it has really helped. I am hoping combining it with an oral oil will get me off the tons of Ibuprofen I have been having to take every day. I am so excited.
Unrefined hemp oil does not have a very long shelf life. The oil quickly goes rancid, unless it is stored in dark containers in a refrigerated environment. People who use unrefined hemp oil generally purchase it in small amounts so that it will not become rancid. The oil is also not suitable for cooking, because it has a very low smoking point. Refined hemp oil is much more shelf stable, although many of the benefits of it are not present after refining.

Cannabis, (genus Cannabis), plant belonging to the family Cannabaceae of the nettle order (Urticales). By some classifications, the genus Cannabis comprises a single species, hemp (Cannabis sativa), a stout, aromatic, erect annual herb that originated in Central Asia and is now cultivated worldwide, including in Europe, southern Asia, the Middle East, India, Africa, and the Americas. A tall canelike variety is raised for the production of hemp fibre, while the female plant of a short branchier variety is prized as the more abundant source of the psychoactive substance tetrahydrocannabinol (THC), the active ingredient of marijuana.


The main and only ingredient in CBD Pain Cream is Cannabidiol. This comes from the Marijuana plant, which has over 400 chemicals in it. Now, this won’t get you high, as it contains no THC. And, CBD is completely legal in all 50 states. Truly, CBD is a breakthrough for reducing pain, inflammation from chronic conditions, and even stress. † And, now you can get in in a convenient topical cream to help erase the pain right on the spot. Within a few minutes, you should notice your pain disappearing. And, CBD Pain Cream saves you from having to be dependent on prescriptions. †

Cannabidiol has been found to act as an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain.[32] It has also been found to act as an inverse agonist of GPR3, GPR6, and GPR12.[13] Although currently classified as orphan receptors, these receptors are most closely related phylogenetically to the cannabinoid receptors.[13] In addition to orphan receptors, CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist,[33] and this action may be involved in its antidepressant,[34][35] anxiolytic,[35][36] and neuroprotective effects.[37][38] It is an allosteric modulator of the μ- and δ-opioid receptors as well.[39] The pharmacological effects of CBD have additionally been attributed to PPARγ agonism and intracellular calcium release.[7]
CBD can be very pricey, and much of it is sold through multi-level marketing schemes, which I don’t like. Dosing isn’t precise (or well-explained); it would be very helpful to have informed guidance in this area. As it is, I break down any product I buy to cost-per-mg, and cost-per-serving, which helps, but I’m still not sure how much is too much or too little. I tell my husband to “listen to [his] body,” but that can be risky.

Of course, hemp oils are not marijuana oils, but this illustrates some of the complications arising from various states legal marijuana programs and medical marijuana programs in 2018.  Some states are allowing for the sales of CBD oils that contain zero % THC, while .03% is the widely accepted standard for industrial hemp classification in other countries and U.S. states. While I am unaware of anyone being prosecuted for simple possession of hemp based CBD oil in the United States in the last 4 years, one should consult their current state laws when purchasing hemp based CBD oils online.  Officials in Tennessee moved recently in February 2018 to shutter over 20 local tobacco and smoke type shops, that were selling CBD gummies among other products, alleging them to be derived from "marijuana". (These charges have all been dropped)  Interestingly, Tennessee is also chief among the U.S. states who are currently growing hemp for CBD extraction, under the provisions of the 2014 Farm Bill.
A. To date, the FDA has not approved a marketing application for marijuana for any indication. The FDA generally evaluates research conducted by manufacturers and other scientific investigators. Our role, as laid out in the Federal Food, Drug, and Cosmetic (FD&C) Act, is to review data submitted to the FDA in an application for approval to assure that the drug product meets the statutory standards for approval.
Wyoming has a particularly narrow law for CBD oil. It is only legal for patients with epilepsy that has not responded to other treatments. Neurologists have to give the state's Department of Health a statement about how the patient needs and would benefit from the CBD, made from hemp extract, and then the patient may be able to receive a card that allows them to receive cannabis with high concentrations of CBD and trace amounts of THC.
Whether the drug and non-drug, cultivated and wild types of Cannabis constitute a single, highly variable species, or the genus is polytypic with more than one species, has been a subject of debate for well over two centuries. This is a contentious issue because there is no universally accepted definition of a species.[54] One widely applied criterion for species recognition is that species are "groups of actually or potentially interbreeding natural populations which are reproductively isolated from other such groups."[55] Populations that are physiologically capable of interbreeding, but morphologically or genetically divergent and isolated by geography or ecology, are sometimes considered to be separate species.[55] Physiological barriers to reproduction are not known to occur within Cannabis, and plants from widely divergent sources are interfertile.[43] However, physical barriers to gene exchange (such as the Himalayan mountain range) might have enabled Cannabis gene pools to diverge before the onset of human intervention, resulting in speciation.[56] It remains controversial whether sufficient morphological and genetic divergence occurs within the genus as a result of geographical or ecological isolation to justify recognition of more than one species.[57][58][59]
In June 2018, the FDA approved the drug Epidiolex, an oral preparation of pure CBD for treatment of two rare and severe forms of epilepsy in children. The drug is made by the GW Pharmaceutical Company and was tested in three randomized, double-blind, placebo-controlled clinical trials, including 516 patients. It was found to be effective in reducing the frequency of seizures.
Along with its better-known counterpart, THC (delta-9-tetrahydrocannabinol, the chemical that produces the marijuana high), CBD is one of more than 400 compounds found in the oils of cannabis plant species, which include marijuana and hemp. Unlike THC, CBD will not make you high. That said, this doesn’t mean CBD is not at all psychoactive, as many assert, says Jahan Marcu, Ph.D., director of experimental pharmacology and behavior at the International Research Center on Cannabis and Mental Health in New York City: “CBD does change cognition. It affects mood, which is why people take it for anxiety. And some find that it makes them more alert.”

^ Jump up to: a b Resstel LB, Tavares RF, Lisboa SF, Joca SR, Corrêa FM, Guimarães FS (January 2009). "5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats". British Journal of Pharmacology. 156 (1): 181–8. doi:10.1111/j.1476-5381.2008.00046.x. PMC 2697769. PMID 19133999.
LEGAL NOTICES: Care By Design products have not been evaluated by the Food and Drug Administration (FDA). This information is not intended to diagnose, treat or cure any disease. This information should not be interpreted as medical advice or treatment. You should consult your physician or other health care professional before starting any medication or supplements. Further, Care By Design does not manufacture, sell or distribute any products that are in violation of California State Law.
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Cannabis is first referred to in Hindu Vedas between 2000 and 1400 BCE, in the Atharvaveda. By the 10th century CE, it has been suggested that it was referred to by some in India as "food of the gods".[116] Cannabis use eventually became a ritual part of the Hindu festival of Holi. One of the earliest to use this plant in medical purposes was Korakkar, one of the 18 Siddhas.[117][118] The plant is called Korakkar Mooli in the Tamil language, meaning Korakkar's herb.[119][120]
Following the success of various pilot programs made possible by the 2014 Farm Bill, hemp is now widely accepted by the public and most lawmakers. In 2018, the US Senate introduced The Hemp Farming Act in its version of The 2018 Farm Bill. Among other things, the act sought to make hemp an agricultural commodity, give states the power to oversee hemp production, and take away the Drug Enforcement Administration’s (DEA) authority over hemp.
Update January 1st, 2018: State laws surrounding CBD are starting to make a grey area even greyer as states such as Indiana are currently seeking to make CBD imported from outside of the state, illegal for residents inside the state that qualify for CBD possession under current state laws. Alaska has made selling hemp based CBD against the law for local marijuana shops to sell, but other stores are still free to sell imported hemp oils. All CBD oils sold at local marijuana shops in Alaska currently, must be produced within the state, under the current state guidelines for marijuana production.

The endocannabinoid system is tonically active in control of pain, as demonstrated by the ability of SR141716A (rimonabant), a CB1 antagonist, to produce hyperalgesia upon administration to mice (Richardson et al 1997). As mentioned above, the ECS is active throughout the neuraxis, including integrative functions in the periacqueductal gray (Walker et al 1999a; Walker et al 1999b), and in the ventroposterolateral nucleus of the thalamus, in which cannabinoids proved to be 10-fold more potent than morphine in wide dynamic range neurons mediating pain (Martin et al 1996). The ECS also mediates central stress-induced analgesia (Hohmann et al 2005), and is active in nociceptive spinal areas (Hohmann et al 1995; Richardson et al 1998a) including mechanisms of wind-up (Strangman and Walker 1999) and N-methyl-D-aspartate (NMDA) receptors (Richardson et al 1998b). It was recently demonstrated that cannabinoid agonists suppress the maintenance of vincristine-induced allodynia through activation of CB1 and CB2 receptors in the spinal cord (Rahn et al 2007). The ECS is also active peripherally (Richardson et al 1998c) where CB1 stimulation reduces pain, inflammation and hyperalgesia. These mechanisms were also proven to include mediation of contact dermatitis via CB1 and CB2 with benefits of THC noted systemically and locally on inflammation and itch (Karsak et al 2007). Recent experiments in mice have even suggested the paramount importance of peripheral over central CB1 receptors in nociception of pain (Agarwal et al 2007)

Cannabis CBD

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