Phytocannabinoids are lipid soluble with slow and erratic oral absorption. While cannabis users claim that the smoking of cannabis allows easy dose titration as a function of rapid onset, high serum levels in a short interval inevitably result. This quick onset is desirable for recreational purposes, wherein intoxication is the ultimate goal, but aside from paroxysmal disorders (eg, episodic trigeminal neuralgia or cluster headache attack), such rapid onset of activity is not usually necessary for therapeutic purposes in chronic pain states. As more thoroughly reviewed elsewhere (Russo 2006b), cannabis smoking produces peak levels of serum THC above 140 ng/mL (Grotenhermen 2003; Huestis et al 1992), while comparable amounts of THC in Sativex administered oromucosally remained below 2 ng/mL (Guy and Robson 2003).
Cannabinoids may offer significant “side benefits” beyond analgesia. These include anti-emetic effects, well established with THC, but additionally demonstrated for CBD (Pertwee 2005), the ability of THC and CBD to produce apoptosis in malignant cells and inhibit cancer-induced angiogenesis (Kogan 2005; Ligresti et al 2006), as well as the neuroprotective antioxidant properties of the two substances (Hampson et al 1998), and improvements in symptomatic insomnia (Russo et al 2007).
The mosaic of laws that govern CBD legality across the globe varies just as much as the legislation across the US. Generally, CBD extract is legal in most countries, but what makes it illegal is where and what it’s extracted from. Most Group of 20 (G20) countries allow CBD extracted from industrial hemp, but not CBD extracted from whole-plant marijuana. Note, however, the differences between the two. Legislation regarding international travel with CBD also varies among countries. For the foreseeable future, the best practice would be to search online, or contact the respective embassies or consulates, before traveling to determine whether your CBD is safe and legal.
In Buddhism, cannabis is generally regarded as an intoxicant and may be a hindrance to development of meditation and clear awareness. In ancient Germanic culture, Cannabis was associated with the Norse love goddess, Freya.[121][122] An anointing oil mentioned in Exodus is, by some translators, said to contain Cannabis.[123] Sufis have used Cannabis in a spiritual context since the 13th century CE.[124]
Cannabinoid agonists produce many effects beyond those mediated directly on receptors, including anti-inflammatory effects and interactions with various other neurotransmitter systems (previously reviewed (Russo 2006a). Briefly stated, THC effects in serotonergic systems are widespread, including its ability to decrease 5-hydroxytryptamine (5-HT) release from platelets (Volfe et al 1985), increase its cerebral production and decrease synaptosomal uptake (Spadone 1991). THC may affect many mechanisms of the trigeminovascular system in migraine (Akerman et al 2003; Akerman et al 2004; Akerman et al 2007; Russo 1998; Russo 2001). Dopaminergic blocking actions of THC (Müller-Vahl et al 1999) may also contribute to analgesic benefits.
Before purchasing any CBD product in these states (aside from the 8 mentioned above)  you must have a medical prescription issued by a certified medical doctor. Each state has a particular concentration of THC it allows to be present in a CBD product, with the percentage ranging from 0.3% – 8%. (See details in table 1.1 below). Even though the legal situation seems to be shifting in a positive direction, if you are in any of these states, it is very important to be aware of the state’s laws towards CBD.
Cannabis has been around for thousands of years and is believed to have originated in South or Central Asia. The two main species of cannabis are Cannabis sativa and Cannabis indica. Both Cannabis sativa and indica contain varying amounts of psychoactive and nonpsychoactive components. Cannabis sativa is more commonly known for its stimulatory, mental effects while Cannabis indica is more known for its relaxing, body-calming effects.
Although global abnormalities in white matter and grey matter are not associated with cannabis abuse, reduced hippocampal volume is consistently found. Amygdalar abnormalities are sometimes reported, although findings are inconsistent.[111][112][113] Preliminary evidence suggests that this effect is largely mediated by THC, and that CBD may even have a protective effect.[114]
Debate continues as to the existence of a clinically significant cannabis withdrawal syndrome with proponents (Budney et al 2004), and questioners (Smith 2002). While withdrawal effects have been reported in recreational cannabis smokers (Solowij et al 2002), 24 volunteers with MS who abruptly stopped Sativex after more than a year of continuous usage displayed no withdrawal symptoms meeting Budney’s criteria. While symptoms recurred after 7–10 days of abstinence from Sativex, prior levels of symptom control were readily re-established upon re-titration of the agent (Wade et al 2006).
This is good news for the best CBD oil companies because the Farm Bill allows for the legal cultivation of industrial hemp, under certain circumstances, which can be a source of CBD. But CBD can also come from non-industrial hemp, namely the marijuana plant that most are more familiar with. Therefore, whether or not CBD oil for pain is legal can be a question of which “version” of the cannabis plant it was sourced from. If it was sourced from industrial hemp, (which contains less than 0.3% THC by volume), and it was cultivated under the Farm Bill, then it is legal.
Chronic pain is a major issue in the health sector and millions of people rely on pain medication to go about their normal lives, but synthetic painkillers are known for causing side effects that make them unsafe for long-term use. Alternative pain treatments like hemp oil have shown a lot of promise for people with injury-related pain, arthritis, and other types of chronic pain.

Whether the drug and non-drug, cultivated and wild types of Cannabis constitute a single, highly variable species, or the genus is polytypic with more than one species, has been a subject of debate for well over two centuries. This is a contentious issue because there is no universally accepted definition of a species.[54] One widely applied criterion for species recognition is that species are "groups of actually or potentially interbreeding natural populations which are reproductively isolated from other such groups."[55] Populations that are physiologically capable of interbreeding, but morphologically or genetically divergent and isolated by geography or ecology, are sometimes considered to be separate species.[55] Physiological barriers to reproduction are not known to occur within Cannabis, and plants from widely divergent sources are interfertile.[43] However, physical barriers to gene exchange (such as the Himalayan mountain range) might have enabled Cannabis gene pools to diverge before the onset of human intervention, resulting in speciation.[56] It remains controversial whether sufficient morphological and genetic divergence occurs within the genus as a result of geographical or ecological isolation to justify recognition of more than one species.[57][58][59]
^ "Fats and fatty acids contents per 100 g (click for "more details") example: avocado oil; user can search for other oils". Nutritiondata.com, Conde Nast for the USDA National Nutrient Database, Standard Release 21. 2014. Retrieved 7 September 2017. Values from Nutritiondata.com (SR 21) may need to be reconciled with most recent release from the USDA SR 28 as of Sept 2017.

Whether the drug and non-drug, cultivated and wild types of Cannabis constitute a single, highly variable species, or the genus is polytypic with more than one species, has been a subject of debate for well over two centuries. This is a contentious issue because there is no universally accepted definition of a species.[54] One widely applied criterion for species recognition is that species are "groups of actually or potentially interbreeding natural populations which are reproductively isolated from other such groups."[55] Populations that are physiologically capable of interbreeding, but morphologically or genetically divergent and isolated by geography or ecology, are sometimes considered to be separate species.[55] Physiological barriers to reproduction are not known to occur within Cannabis, and plants from widely divergent sources are interfertile.[43] However, physical barriers to gene exchange (such as the Himalayan mountain range) might have enabled Cannabis gene pools to diverge before the onset of human intervention, resulting in speciation.[56] It remains controversial whether sufficient morphological and genetic divergence occurs within the genus as a result of geographical or ecological isolation to justify recognition of more than one species.[57][58][59] 

^ A 2016 review also found a statistically significant increase in crash risk associated with marijuana use, but noted that this risk was "of low to medium magnitude."[73] The increase in risk of motor vehicle crash for cannabis use is between 2 and 3 times relative to baseline, whereas that for comparable doses of alcohol is between 6 and 15 times.[74]

Derived from the stalk and seed of cannabis (hemp) plants, cannabidiol (CBD) oil or CBD hemp oil is a natural botanical concentrate that is high in the compound CBD. Of the more than 85 cannabinoids so far identified in the cannabis plant, CBD is the second most common after tetrahydrocannabinol (THC). Unlike THC, CBD is non-psychotropic and therefore doesn’t cause a euphoric high.
Cannabis research suggests medical marijuana could become an effective treatment for diabetic neuropathy. Diabetic neuropathy is a debilitating and sometimes fatal condition caused by diabetes. Diabetics suffer from high blood sugar due to insulin resistance, and this damages nerve cells in the body, causing severe pain. Patients who consumed THC as part of a study found they experienced less pain. Findings are not definitive, however, and further research into cannabis as a treatment for diabetes and associated symptoms is required.

Way, John. It’s amazing how life can be running along great one day, you’re bothering no one, loving others, minding your own business, enjoying your work and then one crooked cop can railroad you. This cop who screwed me over–Robert Bifano– failed to arrest a suicidal AWOL soldier a few years ago and the guy went on to kill his wife and then shot himself. Bifano got sued for his ineptitude.


In 2015, researchers conducted a comprehensive review to get at the heart of CBD and its intervention of addictive behaviors. These researchers gathered 14 studies, nine (9) of which involved animals, while the remaining five (5) involved humans, to find that CBD may indeed have therapeutic properties on opioid, cocaine, and psychostimulant addiction. Further, studies heavily suggest that CBD may also be beneficial in the treatment of marijuana and tobacco addiction. One reason that CBD may be effective as treatment for addictive disorders is its ability to ease the anxiety that leads people to crave drugs like heroin.

In contrast, THC did not tamp down levels of these inflammation-related molecules, called prostaglandins. “These prostaglandins are involved in many processes (such as) memory loss, neuroinflammation, hair loss and vasoconstriction,” he says. That means PET is “highly interesting for medicinal applications, as we can expect fewer adverse effects while still having pharmacologically important effects.” The reduced potency of PET also might put a damper on any interest in the liverwort for recreational use, especially in an era of increasingly loosened cannabis regulation.


In theory, getting a false positive on a drug test from CBD oil should be relatively impossible from pure CBD oil containing less than .3 percent THC. However, because CBD oil is not very well regulated, there is no guarantee that a product contains pure CBD oil, or that its concentration is at a safe or effective level. It is best to use utmost caution and do your research when purchasing a quality CBD oil product to ensure its purity, especially if you need to undergo drug screenings.
Unlike THC, which primarily binds to CB-1 receptors located in the brain, CBD works in the body by manipulating receptors throughout organ tissues, the immune system, the pain response system, the hormonal system, and other whole-body regulatory systems. Basically, since its receptors have been found to exist in virtually every cell and tissue type in the body, CBD is believed to work on every aspect of human health and behavior – from the subcellular level to the whole-body leve and beyond.
CBD, or Cannabidiol, is a compound known as a cannabinoid. Cannabinoids are compounds that act on certain neurotransmitters throughout your body’s Endocannabinoid System (ECS). The ECS is responsible for regulating pain, inflammation, recovery time, sleep, and much more. When CBD is applied, consumed, or vaped, it encourages your ECS to produce more cannabinoids to reduce distress. The CBD in our Pain Rub may be able to alleviate pain and inflammation when it is applied to the desired area.

Hemp oil is a great source of high-quality nutrients and has a long history of use in Eastern culture as a multi-purpose natural remedy. Despite its widespread popularity, prejudice related to its association with Marijuana it has kept it from common use in the West. While Hemp oil contains virtually no THC (the psychoactive element in cannabis) hemp oil is still concerning to some. Thankfully, education is prevailing and the market for hemp oil is growing in the United States, with an increasing number of people seeking it out for its reported health benefits.
“All parts of the plant Cannabis sativa L., whether growing or not; the seeds thereof; the resin extracted from any part of such plant; and every compound manufacture, salt, derivative, mixture, or preparation of such plant, its seeds or resins; but shall not include the mature stalks of such plant fiber produced from such stalks oil or cake made from the seeds of such plant, any other compound, manufacture, salt, derivative, mixture, or preparation of such mature stalks (except the resin extracted therefrom),fiber, oil or cake, or the sterilized seed of such plant which is incapable of germination.”

A a bipartisan group of lawmakers sent a letter to the FDA last week, urging immediate action on the matter. A series of recent actions in New York City, Maine and Ohio cracking down on the sale of CBD foods and drinks have “spurred a tremendous amount of confusion among product manufacturers, hemp farmers, and consumers of these products,” said the letter, as reported by Weedmaps, an information community website for businesses and consumers.
This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Individual weight loss results will vary. By using this site, you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited by Law. US GOVERNMENT PATENT #6,630,507: "CANNABINOIDS AS ANTIOXIDANTS AND NEUROPROTECTANTS
^ Jump up to: a b Resstel LB, Tavares RF, Lisboa SF, Joca SR, Corrêa FM, Guimarães FS (January 2009). "5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats". British Journal of Pharmacology. 156 (1): 181–8. doi:10.1111/j.1476-5381.2008.00046.x. PMC 2697769. PMID 19133999.
There are also other difficulties in researching the effects of cannabis. Many people who smoke cannabis also smoke tobacco.[276] This causes confounding factors, where questions arise as to whether the tobacco, the cannabis, or both that have caused a cancer. Another difficulty researchers have is in recruiting people who smoke cannabis into studies. Because cannabis is an illegal drug in many countries, people may be reluctant to take part in research, and if they do agree to take part, they may not say how much cannabis they actually smoke.[277]

Cannabinoids may offer significant “side benefits” beyond analgesia. These include anti-emetic effects, well established with THC, but additionally demonstrated for CBD (Pertwee 2005), the ability of THC and CBD to produce apoptosis in malignant cells and inhibit cancer-induced angiogenesis (Kogan 2005; Ligresti et al 2006), as well as the neuroprotective antioxidant properties of the two substances (Hampson et al 1998), and improvements in symptomatic insomnia (Russo et al 2007).
The HPRA is the competent authority for authorising medicinal products in Ireland. Its role is to ensure that only products that are safe, effective and of an appropriate quality based on clinical and scientific data can be authorised and supplied as medicines in Ireland (see HPRA’s report: Cannabis for Medical Use - A Scientific Review). At present there are no authorised medicines in Ireland that contain CBD as the only active ingredient. Accordingly, CBD products currently being sold for consumer use are not approved for the prevention or treatment of medical conditions or symptoms associated with such conditions.
It is evident from the name that CBD Balm is a natural serum, which helps in dealing with joint pain, stiffness, inflammation, arthritis as well as various kinds of skin problems like eczema, dry skin etc. The serum also help in lessening muscle soreness, headaches and similar problems successfully. The pain relief serum shows excellent long-time results. The effects and relief obtained from topical application of the serum have been validated by real people, who have used the product.

After ignoring the CBD oil on the shelves of health food stores for months; the state excise police in Indiana began raiding stores recently for CBD oil. According to the State Excise Police, CBD is considered the same as marijuana in the state of Indiana. Even thought that makes zero sense since it does not have any psychoactive chemicals in it at all (or so little as to not count). Thus it is idiocy but must be coming from the top as the Governor is the head cheese they would not be raiding unless he had given the OK. So it is stupid and a waste of taxpayer money. Hitting the health food stores hard; and people will just pay a little more to order it online. CBD oil works for a variety of health conditions. It is big pharma that is trying to keep it off the shelves. But in the end they will lose this one.
If you are living with chronic pain, hemp offers you hope. CBD can be purchased online or over the counter in many forms in every state in the U.S., and many places around the world. The good news is CBD has a very broad safety profile, and you should feel comfortable trying it. Dosing is going to be a key, and we’ll discuss that in a later column. Taking too much won’t harm you, but it might not help you either. Please be sure to talk to your physician about CBD. In my next column, I will offer some tips for having this conversation, particularly if you feel awkward about cannabis or hemp, or suspect your doctor might react badly to your interest.
Over decades, researchers have found that THC may help treat pain, nausea, loss of appetite and other problems, while CBD was thought to be biologically inactive in humans. But in the past 10 years, scientists have concluded that CBD may be quite useful. Dozens of studies have found evidence that the compound can treat epilepsy as well as a range of other illnesses, including anxiety, schizophrenia, heart disease and cancer.
Cannabinoids may offer significant “side benefits” beyond analgesia. These include anti-emetic effects, well established with THC, but additionally demonstrated for CBD (Pertwee 2005), the ability of THC and CBD to produce apoptosis in malignant cells and inhibit cancer-induced angiogenesis (Kogan 2005; Ligresti et al 2006), as well as the neuroprotective antioxidant properties of the two substances (Hampson et al 1998), and improvements in symptomatic insomnia (Russo et al 2007).
My sister has convinced me that I should live a more healthy lifestyle and I think that hemp oil would be a great contributor to that. Your information that hemp oil contains omega fatty acids and proteins and can be used as a cooking substitute only convinces me more. I will start looking into purchasing some pure hemp oil so that I can improve my skin and live a more healthy life.
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